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Review series
Chronic obstructive pulmonary disease • 3: Experimental animal models of pulmonary emphysema
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  1. R Mahadeva1,2,
  2. S D Shapiro
  1. 1Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
  2. 2Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02116, USA
  1. Dr R Mahadeva, Respiratory Medicine Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK;
    rm232{at}cam.ac.uk

Abstract

The use of genetically manipulated mice together with traditional animal studies are steadily increasing our knowledge of the factors important in determining alveolar formation and destruction in emphysema. A review of the animal models used to study emphysema is presented.

  • pulmonary emphysema
  • chronic obstructive pulmonary disease animal models

https://doi.org/10.1136/thorax.57.10.908

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