Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment

A E Redington; Q-H Meng; D R Springall; T J Evans; C Créminon; J Maclouf; S T Holgate; P H Howarth; J M Polak

doi:10.1136/thorax.56.5.351

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Original article

Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment

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	Abstract	Full	Pdf
Apr 2001	61	126	52
May 2001	48	178	29
Jun 2001	14	65	36
Jul 2001	3	47	18
Aug 2001	8	38	7
Sep 2001	6	29	17
Oct 2001	6	27	15
Nov 2001	3	33	13
Dec 2001	3	26	8
Jan 2002	6	25	5
Feb 2002	2	21	9
Mar 2002	9	24	14
Apr 2002	7	19	6
May 2002	3	14	4
Jun 2002	2	21	8
Jul 2002	5	25	9
Aug 2002	2	17	4
Sep 2002	2	6	8
Oct 2002	2	17	12
Nov 2002	1	17	16
Dec 2002	5	22	10
Jan 2003	2	19	21
Feb 2003	6	10	15
Mar 2003	2	11	10
Apr 2003	4	12	10
May 2003	1	15	14
Jun 2003	3	13	9
Jul 2003	12	28	14
Aug 2003	17	32	5
Sep 2003	19	27	10
Oct 2003	18	26	4
Nov 2003	21	40	6
Dec 2003	16	28	9
Jan 2004	23	38	11
Feb 2004	18	38	14
Mar 2004	19	43	8
Apr 2004	22	39	8
May 2004	34	51	6
Jun 2004	46	68	10
Jul 2004	53	69	14
Aug 2004	50	62	17
Sep 2004	33	48	9
Oct 2004	17	35	16
Nov 2004	18	29	9
Dec 2004	12	24	3
Jan 2005	16	24	4
Feb 2005	16	46	16
Mar 2005	21	39	22
Apr 2005	4	11	2
May 2005	9	13	9
Jun 2005	6	19	2
Jul 2005	9	17	8
Aug 2005	12	14	4
Sep 2005	12	19	10
Oct 2005	10	25	12
Nov 2005	13	9	0
Dec 2005	12	23	17
Jan 2006	4	24	16
Feb 2006	10	24	10
Mar 2006	7	16	11
Apr 2006	11	11	8
May 2006	1	9	4
Jun 2006	3	11	6
Jul 2006	5	10	10
Aug 2006	8	11	7
Sep 2006	6	13	7
Oct 2006	10	15	12
Nov 2006	3	13	4
Dec 2006	2	8	6
Jan 2007	4	15	11
Feb 2007	2	16	3
Mar 2007	6	8	1
Apr 2007	4	3	3
May 2007	5	3	4
Jun 2007	3	5	3
Jul 2007	7	7	6
Aug 2007	3	3	3
Sep 2007	1	4	1
Oct 2007	7	6	4
Nov 2007	5	3	2
Dec 2007	1	0	1
Jan 2008	3	4	2
Feb 2008	2	5	2
Mar 2008	4	6	4
Apr 2008	5	3	2
May 2008	6	6	4
Jun 2008	5	2	3
Jul 2008	12	2	2
Aug 2008	22	2	2
Sep 2008	15	5	2
Oct 2008	7	2	4
Nov 2008	7	3	3
Dec 2008	2	1	1
Jan 2009	4	0	0
Feb 2009	6	1	2
Mar 2009	16	1	2
Apr 2009	22	1	1
May 2009	6	3	1
Jun 2009	3	0	1
Jul 2009	7	0	0
Aug 2009	5	1	0
Sep 2009	6	2	1
Oct 2009	15	0	2
Nov 2009	17	1	1
Dec 2009	4	1	1
Jan 2010	6	3	6
Feb 2010	5	3	2
Mar 2010	2	2	0
Apr 2010	4	4	3
May 2010	5	0	1
Jun 2010	14	8	5
Jul 2010	5	4	8
Aug 2010	4	0	0
Sep 2010	11	3	1
Oct 2010	11	4	5
Nov 2010	5	5	4
Dec 2010	8	1	1
Jan 2011	5	1	0
Feb 2011	9	0	1
Mar 2011	5	6	3
Apr 2011	4	6	2
May 2011	5	2	1
Jun 2011	11	0	0
Jul 2011	3	0	0
Aug 2011	5	0	2
Sep 2011	4	2	2
Oct 2011	5	2	0
Nov 2011	6	0	4
Dec 2011	3	14	9
Jan 2012	8	10	5
Feb 2012	3	8	2
Mar 2012	5	5	8
Apr 2012	7	9	8
May 2012	10	5	4
Jun 2012	5	6	8
Jul 2012	9	4	5
Aug 2012	8	13	9
Sep 2012	17	11	2
Oct 2012	17	12	12
Nov 2012	12	12	8
Dec 2012	9	13	5
Jan 2013	16	14	6
Feb 2013	11	9	5
Mar 2013	16	9	13
Apr 2013	16	12	14
May 2013	11	18	7
Jun 2013	3	14	9
Jul 2013	4	14	4
Aug 2013	2	6	1
Sep 2013	7	7	3
Oct 2013	12	11	1
Nov 2013	4	13	2
Dec 2013	3	7	5
Jan 2014	7	10	9
Feb 2014	3	12	4
Mar 2014	10	9	2
Apr 2014	15	8	6
May 2014	29	12	3
Jun 2014	10	18	3
Jul 2014	15	35	3
Aug 2014	6	3	0
Sep 2014	11	6	0
Oct 2014	13	7	4
Nov 2014	11	4	4
Dec 2014	9	4	2
Jan 2015	18	1	4
Feb 2015	10	1	2
Mar 2015	17	17	3
Apr 2015	8	3	2
May 2015	4	11	1
Jun 2015	6	21	0
Jul 2015	9	4	4
Aug 2015	3	4	3
Sep 2015	26	7	3
Oct 2015	6	5	1
Nov 2015	8	6	4
Dec 2015	4	2	0
Jan 2016	11	3	2
Feb 2016	5	6	0
Mar 2016	2	0	4
Apr 2016	1	3	3
May 2016	9	5	3
Jun 2016	3	5	2
Jul 2016	15	4	7
Aug 2016	11	2	0
Sep 2016	14	11	6
Oct 2016	20	12	10
Nov 2016	21	19	6
Dec 2016	13	15	3
Jan 2017	12	16	6
Feb 2017	1	2	3
Mar 2017	3	19	0
Apr 2017	1	17	0
May 2017	0	12	0
Jun 2017	8	19	3
Jul 2017	15	14	4
Aug 2017	15	15	1
Sep 2017	21	21	4
Oct 2017	19	19	0
Nov 2017	20	20	2
Dec 2017	16	14	0
Jan 2018	10	10	6
Feb 2018	25	23	6
Mar 2018	22	23	4
Apr 2018	28	22	1
May 2018	20	18	2
Jun 2018	29	17	3
Jul 2018	19	11	2
Aug 2018	11	9	3
Sep 2018	20	20	1
Oct 2018	106	106	3
Nov 2018	69	69	3
Dec 2018	64	64	1
Jan 2019	52	50	1
Feb 2019	38	37	0
Mar 2019	30	30	7
Apr 2019	9	8	8
May 2019	8	7	4
Jun 2019	6	5	15
Jul 2019	6	5	12
Aug 2019	7	7	3
Sep 2019	5	5	8
Oct 2019	11	11	8
Nov 2019	7	7	4
Dec 2019	9	9	2
Jan 2020	8	8	5
Feb 2020	5	4	1
Mar 2020	14	11	4
Apr 2020	6	6	2
May 2020	5	5	2
Jun 2020	9	8	2
Jul 2020	5	4	2
Aug 2020	9	6	10
Sep 2020	13	13	5
Oct 2020	18	16	6
Nov 2020	10	10	3
Dec 2020	12	12	7
Jan 2021	9	8	5
Feb 2021	6	6	1
Mar 2021	10	10	6
Apr 2021	4	4	4
May 2021	6	5	2
Jun 2021	3	3	2
Jul 2021	8	8	0
Aug 2021	8	7	5
Sep 2021	9	7	1
Oct 2021	10	6	16
Nov 2021	4	4	14
Dec 2021	33	31	4
Jan 2022	15	13	9
Feb 2022	10	7	7
Mar 2022	12	12	10
Apr 2022	16	18	4
May 2022	24	24	7
Jun 2022	31	29	5
Jul 2022	14	12	3
Aug 2022	26	27	3
Sep 2022	31	28	18
Oct 2022	50	48	5
Nov 2022	18	16	3
Dec 2022	10	9	6
Jan 2023	23	21	3
Feb 2023	32	31	6
Mar 2023	8	7	2
Apr 2023	9	6	16
May 2023	8	7	8
Jun 2023	6	6	2
Jul 2023	8	8	3
Aug 2023	21	18	5
Sep 2023	18	18	5
Oct 2023	16	15	4
Nov 2023	42	42	2
Dec 2023	111	111	47
Jan 2024	22	22	49
Feb 2024	22	22	1
Mar 2024	6	5	28
Total	3441	4303	1663

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