Effect of leukotriene receptor antagonist therapy on the risk of asthma exacerbations in patients with mild to moderate asthma: an integrated analysis of zafirlukast trials

Neil C Barnes; Christopher J Miller

doi:10.1136/thorax.55.6.478

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Original article

Effect of leukotriene receptor antagonist therapy on the risk of asthma exacerbations in patients with mild to moderate asthma: an integrated analysis of zafirlukast trials

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Online download statistics by month: June 2000 to March 2024

	Abstract	Full	Pdf
Jun 2000	68	111	92
Jul 2000	27	60	84
Aug 2000	19	32	22
Sep 2000	12	55	35
Oct 2000	15	51	30
Nov 2000	9	42	24
Dec 2000	10	20	6
Jan 2001	17	9	17
Feb 2001	12	52	13
Mar 2001	11	41	23
Apr 2001	9	19	16
May 2001	6	31	8
Jun 2001	4	22	21
Jul 2001	2	19	8
Aug 2001	4	22	11
Sep 2001	4	19	8
Oct 2001	8	17	2
Nov 2001	4	21	3
Dec 2001	3	13	8
Jan 2002	5	20	2
Feb 2002	3	14	7
Mar 2002	7	13	7
Apr 2002	5	17	13
May 2002	6	22	4
Jun 2002	2	12	9
Jul 2002	4	6	4
Aug 2002	3	14	15
Sep 2002	4	12	11
Oct 2002	8	23	23
Nov 2002	7	27	15
Dec 2002	7	9	10
Jan 2003	8	8	8
Feb 2003	7	6	3
Mar 2003	9	10	10
Apr 2003	5	15	22
May 2003	4	18	4
Jun 2003	3	19	16
Jul 2003	13	26	16
Aug 2003	16	18	10
Sep 2003	12	28	7
Oct 2003	32	52	10
Nov 2003	17	25	5
Dec 2003	24	31	13
Jan 2004	43	36	5
Feb 2004	16	23	8
Mar 2004	18	53	30
Apr 2004	20	30	22
May 2004	43	57	6
Jun 2004	48	55	12
Jul 2004	55	64	13
Aug 2004	53	75	12
Sep 2004	33	36	10
Oct 2004	15	29	14
Nov 2004	22	24	9
Dec 2004	17	40	14
Jan 2005	20	47	7
Feb 2005	25	37	22
Mar 2005	14	19	3
Apr 2005	4	18	8
May 2005	6	19	6
Jun 2005	8	16	6
Jul 2005	7	13	7
Aug 2005	16	17	8
Sep 2005	11	17	9
Oct 2005	12	25	12
Nov 2005	16	20	8
Dec 2005	13	13	7
Jan 2006	13	14	8
Feb 2006	4	12	5
Mar 2006	4	21	14
Apr 2006	5	17	14
May 2006	4	6	6
Jun 2006	10	18	13
Jul 2006	8	6	2
Aug 2006	1	11	8
Sep 2006	12	18	12
Oct 2006	7	15	8
Nov 2006	10	9	5
Dec 2006	4	14	11
Jan 2007	3	16	15
Feb 2007	9	10	5
Mar 2007	2	12	9
Apr 2007	10	2	0
May 2007	5	3	4
Jun 2007	8	5	5
Jul 2007	5	3	7
Aug 2007	6	2	5
Sep 2007	10	8	5
Oct 2007	9	4	5
Nov 2007	10	2	2
Dec 2007	9	2	2
Jan 2008	7	2	0
Feb 2008	10	7	5
Mar 2008	12	4	5
Apr 2008	8	0	4
May 2008	13	5	5
Jun 2008	4	0	2
Jul 2008	5	2	1
Aug 2008	4	3	6
Sep 2008	8	4	3
Oct 2008	10	3	2
Nov 2008	13	3	5
Dec 2008	4	1	1
Jan 2009	9	2	2
Feb 2009	6	2	6
Mar 2009	9	3	1
Apr 2009	10	2	5
May 2009	2	4	5
Jun 2009	3	0	3
Jul 2009	5	0	3
Aug 2009	6	0	0
Sep 2009	2	0	2
Oct 2009	12	1	1
Nov 2009	8	4	1
Dec 2009	6	1	0
Jan 2010	7	3	4
Feb 2010	6	0	1
Mar 2010	7	1	1
Apr 2010	11	7	6
May 2010	11	2	2
Jun 2010	11	7	6
Jul 2010	7	0	5
Aug 2010	3	1	2
Sep 2010	9	1	1
Oct 2010	5	1	2
Nov 2010	7	3	3
Dec 2010	3	2	1
Jan 2011	2	0	0
Feb 2011	5	1	9
Mar 2011	4	1	1
Apr 2011	7	2	2
May 2011	7	5	2
Jun 2011	7	3	3
Jul 2011	7	0	0
Aug 2011	7	1	1
Sep 2011	7	2	0
Oct 2011	14	5	4
Nov 2011	9	3	4
Dec 2011	12	7	4
Jan 2012	1	7	5
Feb 2012	10	3	5
Mar 2012	12	2	4
Apr 2012	4	5	5
May 2012	12	16	8
Jun 2012	12	11	8
Jul 2012	17	16	6
Aug 2012	12	4	8
Sep 2012	14	5	10
Oct 2012	14	18	12
Nov 2012	17	16	9
Dec 2012	10	15	7
Jan 2013	15	10	5
Feb 2013	10	7	3
Mar 2013	15	9	6
Apr 2013	15	14	7
May 2013	12	14	6
Jun 2013	15	10	3
Jul 2013	7	3	1
Aug 2013	11	6	4
Sep 2013	5	7	4
Oct 2013	2	3	3
Nov 2013	16	7	4
Dec 2013	8	3	6
Jan 2014	4	2	1
Feb 2014	5	9	4
Mar 2014	10	10	2
Apr 2014	12	15	10
May 2014	7	11	11
Jun 2014	4	2	1
Jul 2014	9	10	9
Aug 2014	16	24	5
Sep 2014	5	31	1
Oct 2014	5	64	3
Nov 2014	6	49	4
Dec 2014	7	20	3
Jan 2015	5	9	8
Feb 2015	4	10	6
Mar 2015	10	16	1
Apr 2015	8	7	4
May 2015	4	7	3
Jun 2015	5	3	1
Jul 2015	8	1	4
Aug 2015	10	2	4
Sep 2015	7	7	1
Oct 2015	3	0	1
Nov 2015	2	7	7
Dec 2015	7	3	1
Jan 2016	6	5	2
Feb 2016	2	5	2
Mar 2016	4	2	5
Apr 2016	5	4	0
May 2016	5	8	4
Jun 2016	1	6	1
Jul 2016	9	2	4
Aug 2016	7	4	3
Sep 2016	9	3	3
Oct 2016	12	6	7
Nov 2016	17	8	5
Dec 2016	5	4	2
Jan 2017	12	10	6
Feb 2017	8	7	4
Mar 2017	4	16	6
Apr 2017	1	23	2
May 2017	1	37	2
Jun 2017	3	14	2
Jul 2017	11	9	1
Aug 2017	18	12	3
Sep 2017	26	24	4
Oct 2017	18	10	3
Nov 2017	13	11	3
Dec 2017	16	6	1
Jan 2018	14	10	2
Feb 2018	13	7	1
Mar 2018	35	33	0
Apr 2018	86	86	0
May 2018	68	62	3
Jun 2018	42	28	3
Jul 2018	15	13	0
Aug 2018	20	10	2
Sep 2018	60	10	2
Oct 2018	107	73	4
Nov 2018	83	49	11
Dec 2018	80	48	0
Jan 2019	58	28	3
Feb 2019	57	32	3
Mar 2019	44	11	6
Apr 2019	39	6	9
May 2019	41	6	2
Jun 2019	56	6	4
Jul 2019	30	4	5
Aug 2019	45	9	4
Sep 2019	33	3	3
Oct 2019	42	12	4
Nov 2019	15	7	7
Dec 2019	11	9	3
Jan 2020	11	5	4
Feb 2020	8	3	6
Mar 2020	8	8	7
Apr 2020	4	4	4
May 2020	10	4	6
Jun 2020	5	3	1
Jul 2020	4	4	2
Aug 2020	7	5	5
Sep 2020	16	16	3
Oct 2020	18	14	9
Nov 2020	15	11	3
Dec 2020	14	14	3
Jan 2021	8	7	6
Feb 2021	8	8	3
Mar 2021	7	5	6
Apr 2021	6	6	3
May 2021	8	8	1
Jun 2021	5	5	1
Jul 2021	7	7	3
Aug 2021	30	30	5
Sep 2021	11	11	2
Oct 2021	17	17	19
Nov 2021	25	21	14
Dec 2021	31	33	10
Jan 2022	18	17	10
Feb 2022	2	3	0
Mar 2022	22	22	16
Apr 2022	21	11	6
May 2022	32	23	7
Jun 2022	31	25	11
Jul 2022	13	11	3
Aug 2022	23	21	2
Sep 2022	22	16	8
Oct 2022	46	44	4
Nov 2022	12	12	5
Dec 2022	7	7	2
Jan 2023	58	29	6
Feb 2023	35	35	4
Mar 2023	9	7	3
Apr 2023	10	9	12
May 2023	12	10	9
Jun 2023	14	12	5
Jul 2023	15	15	5
Aug 2023	28	22	7
Sep 2023	20	14	2
Oct 2023	23	19	1
Nov 2023	16	16	0
Dec 2023	24	25	3
Jan 2024	28	29	4
Feb 2024	18	18	9
Mar 2024	22	22	4
Total	4109	4296	1899

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