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Letters to the editor
Nasal provocation with AMP
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We read with interest the article on histamine release following nasal provocation with adenosine 5′-monophosphate (AMP) recently published in Thorax by Polosaet al.1 This is a further in vivo demonstration of the histamine releasing ability of adenosine in the respiratory tract. However, in contrast to the in vitro studies described in the paper where adenosine exerts a modulatory effect on mast cell mediator release, we have demonstrated the direct histamine releasing ability of this molecule on mast cells in the bronchoalveolar lavage (BAL) fluid.2 ,3 In samples of BAL fluid from 37 of 54 patients attending hospital for routine bronchoscopy, adenosine alone caused histamine release (maximum 20.6 (2.5)% of the …