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Nasal provocation with AMP
  1. MADELEINE ENNIS,
  2. PAUL FORSYTHE
  1. LORCAN P A MCGARVEY,
  2. LIAM G HEANEY,
  3. JOSEPH MACMAHON
  1. Department of Clinical Biochemistry
  2. Institute of Clinical Science
  3. The Queen’s University of Belfast
  4. Belfast BT12 6BJ, UK
  5. Department of Respiratory Medicine
  6. Belfast City Hospital
  7. Belfast BT9 7AB, UK

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We read with interest the article on histamine release following nasal provocation with adenosine 5′-monophosphate (AMP) recently published in Thorax by Polosaet al.1 This is a further in vivo demonstration of the histamine releasing ability of adenosine in the respiratory tract. However, in contrast to the in vitro studies described in the paper where adenosine exerts a modulatory effect on mast cell mediator release, we have demonstrated the direct histamine releasing ability of this molecule on mast cells in the bronchoalveolar lavage (BAL) fluid.2 ,3 In samples of BAL fluid from 37 of 54 patients attending hospital for routine bronchoscopy, adenosine alone caused histamine release (maximum 20.6 (2.5)% of the …

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