Article Text

Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates?
  1. C Leroyer,
  2. L Perfetti,
  3. A Cartier,
  4. J L Malo
  1. DEpartment of Chest Medicine, Hôpital du Sacré-Coeur, Gouin, Montréal Canada.


The case history is described of a worker who presented with a history suggestive of reactive airways dysfunction syndrome which occurred after an acute high level inhalation of diphenylmethane diisocyanate. Further exposure at work, at a time when concentrations of isocyanates were no longer "irritant", suggested occupational asthma; this diagnosis was confirmed by a specific inhalation challenge test.

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