Article Text

Occupational asthma in an isothiazolinone manufacturing plant.
  1. S J Bourke,
  2. R P Convery,
  3. S C Stenton,
  4. R M Malcolm,
  5. D J Hendrick
  1. Department of Respiratory Medicine, Newcastle General Hospital, University of Newcastle upon Tyne, UK.


    A chemical plant operator developed asthma five months after starting work in an isothiazolinone manufacturing plant. He described symptoms of late asthmatic reactions after work with isothiazolinone. Airway responsiveness to methacholine improved tenfold when he was removed from the plant for 18 days. A workplace challenge study then resulted in a deterioration in airway responsiveness to its earlier level and in progressive falls in forced expiratory volume in one second (FEV1) over three days at work compared with control days, indicating statistically significant late asthmatic reactions of increasing severity.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.