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Use of nebulised liposomal amphotericin B in the treatment of Aspergillus fumigatus empyema.
  1. I F Purcell,
  2. P A Corris
  1. Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne, UK.


    A 28 year old man with asthma, bronchopulmonary aspergillosis, pulmonary thromboembolic disease, and pulmonary hypertension developed Aspergillus fumigatus empyema complicating a pneumothorax. His condition progressively deteriorated despite treatment with intravenous and intrapleural amphotericin B, but improved promptly after substituting nebulised liposomal amphotericin B and oral itraconazole. This experience suggests that nebulised liposomal amphotericin B is well tolerated and merits further assessment in the treatment of pulmonary fungal disease.

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