Article Text

Download PDFPDF
Effect of inhaled menthol on citric acid induced cough in normal subjects.
  1. A H Morice,
  2. A E Marshall,
  3. K S Higgins,
  4. T J Grattan
  1. University Department of Medicine and Pharmacology, Royal Hallamshire Hospital, Sheffield, UK.

    Abstract

    BACKGROUND--Menthol is a commonly used ingredient in many over the counter cough remedies, but there is little objective evidence as to its efficacy. METHODS--Twenty healthy subjects received a cough challenge consisting of five inhalations of 33 mumol citric acid from an air driven dosimeter. The challenge was repeated at hourly intervals for five hours. Five minutes before each challenge subjects inhaled, in a randomised design, either menthol 75% in eucalyptus oil or one of two placebos (pine oil or air). RESULTS--Menthol inhalation caused a reduction in evoked cough when compared with either placebo. CONCLUSIONS--Menthol is an effective antitussive agent in an evoked cough model.

    Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.