Article Text

Download PDFPDF

Protriptyline treatment of sleep hypoxaemia in Duchenne muscular dystrophy.
  1. P E Smith,
  2. R H Edwards,
  3. P M Calverley
  1. Muscle Research Centre, University Department of Medicine, Fazakerley Hospital, Liverpool.


    Protriptyline 20 mg daily reduced the total time spent in rapid eye movement sleep in an open study in four subjects with Duchenne muscular dystrophy. Sleep related hypoxaemia and episodes of desaturation were reduced. Anticholinergic side effects were prominent, however, in these patients, precluding its use for regular treatment.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.