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Effect of prednisolone on theophylline pharmacokinetics in patients with chronic airflow obstruction.
  1. R J Fergusson,
  2. C M Scott,
  3. P Rafferty,
  4. J Gaddie


    The effect of prednisolone on the elimination kinetics of theophylline was studied in a group of nine patients with chronic airflow obstruction. Volume of distribution, plasma half life, and clearance after a single intravenous dose of aminophylline (5.6 mg/kg) were unchanged by prednisolone treatment (20 mg daily for three weeks). The metabolism of an intravenous bolus of theophylline is not influenced by oral prednisolone.

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