Article Text

Download PDFPDF
Dual effect of prostaglandin E2 on normal airways smooth muscle in vivo
  1. EH Walters,
  2. BH Davies
  1. Asthma Research Unit, Sully Hospital, Cardiff


    Inhalation of prostaglandin E2 by normal subjects caused initial bronchoconstriction followed by the predominant effect of bronchodilatation, which was maximal by 15 minutes. The degree of bronchoconstriction seen in the early phase appeared to be related to the initial tone of airways smooth muscle and was exaggerated after bronchodilatation with a large dose of ipratropium bromide. Bronchoconstriction induced by prostaglandin E2 is a direct effect on muscle and not secondary to a vagal reflex initiated by airways irritant receptors.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.