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Hypothalamo-pituitary-adrenal function in intrinsic non-atopic asthma.
  1. J V Collins,
  2. D Bellamy,
  3. M G Britton,
  4. J Townsend,
  5. D J Brown


    Sixteen patients with intrinsic non-atopic asthma with persistent wheezing who had never been treated with corticosteroids showed normal adrenocortical responses to prolonged stimulation with Tetracosactin Depot. In a subgroup of six patients the hypothalamo-pituitary-adrenal (HPA) response to a standard insulin stress test was normal. It is concluded that impaired responsiveness of the HPA axis is unlikely to be a common factor in initiating or maintaining airways obstruction in patients with intrinsic asthma.

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