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Cardiorespiratory effects of protamine after cardiopulmonary bypass in man
  1. J. Jastrzebski,
  2. M. K. Sykes,
  3. D. G. Woods
  1. Institute of Haematology, Warsaw
  2. Department of Anaesthetics, Royal Postgraduate Medical School, London W12 0HS
  3. Anaesthetic Department, Hammersmith Hospital, Du Cane Road, London W12 0HS


    Jastrzebski, J., Sykes, M. K., and Woods, D. G. (1974).Thorax, 29, 534-538. Cardiorespiratory effects of protamine after cardiopulmonary bypass in man. The cardiorespiratory changes following the injection of protamine sulphate (6 mg/kg) were studied in 15 patients who had undergone cardiopulmonary bypass. There was a transient fall in arterial pressure and a more prolonged increase in pulmonary artery pressure. There was a significant fall in arterial oxygen tension which was mainly due to a reduction in mixed venous oxygen tension resulting from a fall in cardiac output. Dead space/tidal volume ratio and percentage shunt did not change significantly.

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