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Effect of disodium cromoglycate (Intal) on sputum protein composition
  1. Sandra Heilpern1,
  2. A. S. Rebuck
  1. Thoracic Unit, The Royal North Shore Hospital of Sydney, Sydney, Australia
  2. Department of Medicine, The University of Sydney, Sydney, Australia


    The protein content in the sputum of nine patients with asthma was compared with that in 11 non-asthmatic patients by a method of gel electrophoresis. It was found that the albumin content was significantly higher in the sputum of the asthmatics than of the non-asthmatics (P<0·01). A further 11 asthmatic patients who were taking disodium cromoglycate (Intal) as part of their treatment had sputum albumin levels indistinguishable from the non-asthmatics. When patients with asthma were then studied serially, before and after disodium cromoglycate therapy, the albumin content returned to non-asthmatic levels within two days of starting treatment. It is suggested that disodium cromoglycate has a previously unrecognized action in altering sputum proteins.

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    • 1 1 Address for reprints: Mrs. S. Heilpern, Thoracic Unit, Royal North Shore Hospital of Sydney, St. Leonards 2065, N.S.W., Australia