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Methotrexate pneumonitis: case report and review of the literature
  1. Michael E. Whitcomb,
  2. Marvin I. Schwarz,
  3. Douglass C. Tormey
  1. Department of Medicine, Walter Reed General Hospital
  2. Division of Medicine, Walter Reed Institute of Research


    Methotrexate has been recommended for long-term therapy of an increasing number of diseases including acute lymphoblastic leukaemia, psoriasis and other chronic dermatoses, Wegener's granulomatosis, and multiple solid tumours. Acute pneumonitis is a known complication of methotrexate therapy. An additional case is reported and the clinical features of the 13 previous cases are summarized. Clinical and radiographic evidence of acute pneumonitis associated with eosinophilia and a rapid clearing with steroid treatment is the characteristic syndrome.

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