Article Text

Download PDFPDF

Remission in Goodpasture's syndrome: report of two patients treated by immunosuppression and review of the literature
  1. Anthony Seaton,
  2. J. Milo Meland,
  3. N. Leroy Lapp
  1. Department of Medicine, Cardiopulmonary Division, West Virginia University Medical Center, Morgantown, West Virginia 26506


    Two patients with Goodpasture's syndrome are reported. One showed an apparently spontaneous remission and has survived in good health for over five years since the onset of his illness; he was treated for part of this time with steroids and chlorambucil. The second patient failed to respond to steroids but appeared to improve rapidly from a moribund state on administration of azathioprine; he remains well, although in mild renal failure, over a year later.

    The management of 35 other patients reported to have survived this illness is reviewed. It appears that both the renal and pulmonary features of Goodpasture's syndrome may undergo spontaneous remission, and that the latter can sometimes be suppressed with steroid or immunosuppressant therapy. On four occasions the pulmonary manifestations of the disease have been arrested by nephrectomy.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.