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Transplantation of the heart and both lungs
  1. D. K. C. Cooper1
  1. Department of Surgery, National Heart Hospital, London

    I. Historical review


    Transplantation of the heart and both lungs is being considered as a clinical possibility in several surgical centres today. This paper reviews the experimental development of surgical techniques in this field. In the 1940s Demikhov in the U.S.S.R. succeeded in developing a technique by which he could carry out cardiopulmonary transplantation without the use of any artificial means of recipient support during the procedure. He obtained survivors for up to six days; late deaths occurred mainly from pulmonary complications. The techniques and results of subsequent workers using hypothermia or pump-oxygenator support are reviewed. Recent work has focused on the problem of the return of spontaneous respiration following denervation of the lungs which, of necessity, occurs during this procedure.

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    • 1 British Heart Foundation Surgical Research Fellow.