Natural lung aging is marked by molecular changes that occur during development,
maturation, and late-life decline. At the cellular and whole organ level, degenerative …

Introduction or background The adult lung is a complex organ whose large surface area
interfaces extensively with both the environment and circulatory system. Yet, in spite of the …

Werner's syndrome (WS) is an inherited disease characterized by genomic instability and
premature aging. The WS gene encodes a protein (WRN) with helicase and exonuclease …

Background: The organ supply shortage continues to be a public health care crisis, with
nearly 20 people dying each day awaiting transplantation. Inability to obtain consent …

Type 2 alveolar epithelial cells (AEC2) are regarded as the progenitor population of the
alveolus responsible for injury repair and homeostatic maintenance. Depletion of this …

High levels of rRNA synthesis by RNA polymerase I are important for cell growth and
proliferation. In vitro studies have indicated that the formation of a stable complex between …

Soon after infection, poliovirus (PV) shuts off host-cell transcription, which is catalysed by all
three cellular RNA polymerases. rRNA constitutes more than 50% of all cellular RNA and is …

Background Lung ageing, a significant risk factor for chronic human lung diseases such as
COPD and emphysema, is characterised by airspace enlargement and decreasing lung …

Background: A persistent shortage of organs and inexhaustible waiting lists continue to
result in many people dying while awaiting transplantation. On July 1, 2006, the California …

Objective To identify factors that contribute to intent to donate organs in Hispanic American
individuals. Design Cross-sectional telephone surveys. Setting Four southern California …