Antibiotic Management of Lung Infections in Cystic Fibrosis. I. The Microbiome, Methicillin-Resistant Staphylococcus aureus, Gram-Negative Bacteria, and Multiple …

JF Chmiel, TR Aksamit, SH Chotirmall… - Annals of the …, 2014 - atsjournals.org
Despite significant advances in treatment strategies targeting the underlying defect in cystic
fibrosis (CF), airway infection remains an important cause of lung disease. In this two-part …

Evidence-based management of paediatric primary spontaneous pneumothorax

PD Robinson, P Cooper, SC Ranganathan - Paediatric respiratory reviews, 2009 - Elsevier
The exact incidence of paediatric primary spontaneous pneumothorax (PSP) is unclear,
although PSP incidence in the general population is between 6 and 18 per 100000. PSP …

Early lung disease in infants and preschool children with cystic fibrosis. What have we learned and what should we do about it?

SC Ranganathan, GL Hall, PD Sly, SM Stick… - American journal of …, 2017 - atsjournals.org
The past decade has seen significant advances in understanding of the pathogenesis and
progression of lung disease in cystic fibrosis (CF). Pulmonary inflammation, infection, and …

Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening

PD Sly, S Brennan, C Gangell, N De Klerk… - American journal of …, 2009 - atsjournals.org
Rationale: The promise of newborn screening (NBS) for cystic fibrosis (CF) has not been
fully realized, and the extent of improvement in respiratory outcomes is unclear. We …

Progression of early structural lung disease in young children with cystic fibrosis assessed using CT

LS Mott, J Park, CP Murray, CL Gangell, NH de Klerk… - Thorax, 2012 - thorax.bmj.com
Background Cross-sectional studies implicate neutrophilic inflammation and pulmonary
infection as risk factors for early structural lung disease in infants and young children with …

[HTML][HTML] A Three-Way Comparison of Tuberculin Skin Testing, QuantiFERON-TB Gold and T-SPOT.TB in Children

TG Connell, N Ritz, GA Paxton, JP Buttery, N Curtis… - PloS one, 2008 - journals.plos.org
Background There are limited data comparing the performance of the two commercially
available interferon gamma (IFN-γ) release assays (IGRAs) for the diagnosis of tuberculosis …

PRAGMA-CF. A quantitative structural lung disease computed tomography outcome in young children with cystic fibrosis

T Rosenow, MCJ Oudraad, CP Murray… - American journal of …, 2015 - atsjournals.org
Rationale: Chest computed tomography (CT) is the gold standard for demonstrating cystic
fibrosis (CF) airway disease. However, there are no standardized outcome measures …

Performance of a whole blood interferon gamma assay for detecting latent infection with Mycobacterium tuberculosis in children

TG Connell, N Curtis, SC Ranganathan, JP Buttery - Thorax, 2006 - thorax.bmj.com
Background: The diagnosis of latent Mycobacterium tuberculosis (MTB) infection with a
tuberculin skin test (TST) in children is complicated by the potential influence of prior …

[HTML][HTML] Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children

MS Muhlebach, BT Zorn, CR Esther, JE Hatch… - PLoS …, 2018 - journals.plos.org
The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however,
little is known about its relationship to early disease progression. To better understand the …

Lung function in infants with cystic fibrosis diagnosed by newborn screening

BM Linnane, GL Hall, G Nolan, S Brennan… - American journal of …, 2008 - atsjournals.org
Rationale: Progressive lung damage in cystic fibrosis (CF) starts in infancy, and early
detection may aid preventative strategies. Objectives: To measure lung function in infants …