Protective immunity against influenza virus infection is mediated by neutralizing antibodies,
but the precise role of T cells in human influenza immunity is uncertain. We conducted …

Non-typeable Haemophilus influenzae (NTHi) is an ubiquitous commensal-turned-pathogen
that colonises the respiratory mucosa in airways diseases including Chronic Obstructive …

Under normal physiological conditions, the lung remains an oxygen rich environment.
However, prominent regions of hypoxia are a common feature of infected and inflamed …

Background Alterations in the composition of the lung microbiome associated with adverse
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …

Background Asthma is a chronic inflammatory disease involving diverse cells and mediators
whose interconnectivity and relationships to asthma severity are unclear. Objective We …

IL-10 is an important immunosuppressive cytokine that can down-regulate expression of
other cytokines and has been shown to down-regulate itself. We show, in this study, that …

Background The aetiology of acute exacerbations of COPD (AECOPD) is incompletely
understood. Understanding the relationship between chronic bacterial airway infection and …

Background and Purpose Currently, there are no licensed vaccines and limited antivirals for
the treatment of COVID‐19. Heparin (delivered systemically) is currently used to treat …

BACKGROUND: Studies with monocyte-derived macrophages (MDMs) and animal models
have suggested a role for alternatively activated (M2) macrophages in asthmatic …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) are susceptible to
respiratory viral infections that cause exacerbations. The mechanisms underlying this …