Chronic obstructive pulmonary disease (COPD) is a disorder characterized by reduced
maximum expiratory flow and slow forced emptying of the lungs; features which do not …

Considering the important surface in pulmonary circulation where blood can interact with the
endothelium, the maintenance of blood fluidity through the lung, by antithrombotic pathways …

The acute effects of inhaled nitric oxide (NO)(40 ppm in air) on pulmonary (PVR) and
systemic (SVR) vascular resistance were compared with those of an intravenous infusion of …

Background Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of
prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and …

A clinically applicable, standardized method for assessing functional results after lung
transplantation is required to evaluate factors that may affect long-term outcome, to permit …

Background Recently in France, primary pulmonary hypertension developed in a cluster of
patients exposed to derivatives of fenfluramine in appetite suppressants (anorexic agents) …

Level of Evidence A Data derived from multiple randomised clinical trials or meta-analyses
Level of Evidence B Data derived from a single randomised clinical trial or large non …

Background. Endothelial cells release endothelium-derived relaxing factor (EDRF) in a
variety of vascular beds, including the pulmonary circulation. However, the role of EDRF …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …

BACKGROUND Primary pulmonary hypertension (PPH), resulting from occlusion of small
pulmonary arteries, is a devastating condition. Mutations of the bone morphogenetic protein …