Leukotrienes and lipoxins: structures, biosynthesis, and biological effects
B Samuelsson, SE Dahlen, JÅ Lindgren, CA Rouzer… - Science, 1987 - science.org
Arachidonic acid is released from membrane phospholipids upon cell stimulation (for
example, by immune complexes and calcium ionophores) and converted to leukotrienes by …
example, by immune complexes and calcium ionophores) and converted to leukotrienes by …
The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo
Lipoxins (LXs) and aspirin-triggered LX (ATL) are trihydroxytetraene-containing eicosanoids
generated from arachidonic acid that are distinct in structure, formation, and function from …
generated from arachidonic acid that are distinct in structure, formation, and function from …
International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors
C Brink, SE Dahlén, J Drazen, JF Evans, DWP Hay… - Pharmacological …, 2003 - ASPET
The leukotrienes and lipoxins are biologically active metabolites derived from arachidonic
acid. Their diverse and potent actions are associated with specific receptors. Recent …
acid. Their diverse and potent actions are associated with specific receptors. Recent …
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society …
Task Force, supported by the European Respiratory Society and American Thoracic Society …
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
SE Dahlén, J Björk, P Hedqvist… - Proceedings of the …, 1981 - National Acad Sciences
Leukotrienes B4, C4, and D4, members of a recently discovered family of substances
biosynthesized from arachidonic acid, were found to have potent microvascular actions in …
biosynthesized from arachidonic acid, were found to have potent microvascular actions in …
Leukotrienes are potent constrictors of human bronchi
SE Dahlén, P Hedqvist, S Hammarström… - Nature, 1980 - nature.com
Slow reacting substance of anaphylaxis (SRS-A) is released by various stimuli, including
immunological challenge, and has long been considered an important mediator of …
immunological challenge, and has long been considered an important mediator of …
[HTML][HTML] Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
LE Reinius, N Acevedo, M Joerink, G Pershagen… - PloS one, 2012 - journals.plos.org
Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …
measured by a large number of methods, now even in a genome-wide manner for hundreds …
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
DE Shaw, AR Sousa, SJ Fowler… - European …, 2015 - Eur Respiratory Soc
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …
companies and six patient organisations with the objective of improving the understanding …
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma
Rationale: The treatment effect of golimumab, a human monoclonal antibody against tumor
necrosis factor (TNF)-α, in severe persistent asthma is unknown. Objectives: To assess the …
necrosis factor (TNF)-α, in severe persistent asthma is unknown. Objectives: To assess the …
Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics
B Dahlen, EWA Nizankowska, A Szczeklik… - American journal of …, 1998 - atsjournals.org
From bronchoprovocation studies and investigations of the acute effects of drugs that inhibit
leukotrienes (LT), the hypothesis has emerged that leukotrienes are important mediators of …
leukotrienes (LT), the hypothesis has emerged that leukotrienes are important mediators of …