Pulmonary arterial hypertension (PAH) has a multifactorial pathobiology. Vasoconstriction,
remodeling of the pulmonary vessel wall, and thrombosis contribute to increased pulmonary …

Transforming growth factor-β (TGF-β) is extensively involved in the development of fibrosis
in different organs. Overproduction or potentiation of its profibrotic effects leads to an …

Pulmonary arterial hypertension (PAH) is a rare disorder that may be hereditable (HPAH),
idiopathic (IPAH), or associated with either drug-toxin exposures or other medical …

Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …

Idiopathic pulmonary fibrosis (IPF) is characterized by distorted lung architecture and loss of
respiratory function. Enhanced (myo) fibroblast activation, ECM deposition, and alveolar …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by
distorted lung architecture and loss of respiratory function. Alveolar epithelial cell injury and …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually lethal
fibrotic lung disease characterized by profound changes in epithelial cell phenotype and …

The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor present in
most cell types. Upon ligand binding, the GR is activated and translocates into the nucleus …

The role of endogenous inducers of inflammation is poorly understood. To produce the
proinflammatory master cytokine interleukin (IL)-1β, macrophages need double stimulation …