The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and
energy homeostasis. Administration of peptidic MC4R antagonists (usually by intracerebro …

The design, synthesis, and structure− activity relationship development of naphthalene-
derived human CCR8 antagonists is described. In vitro binding assay results of these …

The strategy developed for an asymmetric synthesis of (+)-meloscine (1) features an early
incorporation of the aromatic ring in 1 as the 5-benzyl substituent in 2. The highly …

Background Expression of the T-cell-associated chemokine receptor CCR8 and its ligand
CCL1 have been demonstrated to be elevated in patients with asthma. CCR8 deficiency or …

2-Alkyl-and 2, 4-dialkyl-3-iodo-1-oxocyclohexan-2, 4-carbolactones undergo lithium
hydroxide-and lithium alkoxide-induced fragmentation reactions to provide butenolides, γ …

Asymmetric Synthesis and Fragmentation Reactions of 2-Alkyl- and 2,4-Dialkyl-3-iodo- I-oxocyclohexan-2,4-carbolactones.
Single E Page 1 TETRAHEDRON LETTERS Tetrahedron Letters 39(1998)4203-4206 …

Stereoselective Dihydroxylation of 2-Alkyl- and 2,4-dialkyl-2-amido-3-cyclohexen-l-ones.
Synthesis of Enantiomerically Related 2 Page 1 TETRAHEDRON LETTERS Tetrahedron ~tters39(1998)6663-6666 …

2-Alkyl-and 2, 4-dialkyl-3-iodo-1-oxocyclohexan-2, 4-carbolactones undergo ammonia-
promoted fragmentation reactions to provide butenolides, γ-butyrolactone, and/or β, γ …

A series of yellow dyes derived from 4, 4'-diaminodiphenylmethane and acetoacetanilide
derivatives has been synthesized. The flow birefringent properties of the dyes have been …

A 20-step asymmetric synthesis of the core structure of the Melodinus alkaloids has been
developed. The key features involve an acid-catalyzed intramolecular Mannich cyclization to …