Background. The majority of patients with cystic fibrosis die in early adulthood of lung
disease. Lung transplantation is a treatment option for patients with advanced pulmonary …

Abstract Background and Methods. Both the clinical manifestations of cystic fibrosis and the
genotypes of patients are heterogeneous, but the associations between the two are not …

Rationale: The Third National Health and Nutrition Examination Survey (NHANES III)
reference is currently recommended for interpreting spirometry results, but it is limited by the …

Allelic heterogeneity in disease-causing genes presents a substantial challenge to the
translation of genomic variation into clinical practice. Few of the almost 2,000 variants in the …

Background Polymorphisms in genes other than the cystic fibrosis transmembrane
conductance regulator (CFTR) gene may modify the severity of pulmonary disease in …

Since the earliest days of cystic fibrosis (CF) treatment, patient data have been recorded and
reviewed in order to identify the factors that lead to more favourable outcomes. Large data …

Background: Chronic progressive lung disease is the most prominent cause of morbidity and
death in patients with cystic fibrosis (CF), but severity of lung disease and rate of lung …

Background Anecdotal reports suggest an increased frequency of certain cancers in patients
with cystic fibrosis, the commonest genetic disorder of whites. One third of patients with …

The frequency, prevalence, and mortality patterns of cystic fibrosis were analyzed in 3,795
patients documented in the Canadian Patient Data Registry in 1970–1989. Cystic fibrosis …

Objectives: To evaluate the effects of a 3-year home exercise program on pulmonary
function and exercise tolerance in mildly to moderately impaired patients with cystic fibrosis …