MicroRNAs (miRNAs) are versatile regulators of gene expression in higher eukaryotes. In
order to silence many different mRNAs in a precise manner, miRNA stability and efficacy is …

We studied all patients with community-acquired pneumonia who were admitted to our 800-
bed adult acute care hospital from 1 November 1981 to 15 March 1987. The 719 patients …

The advent of massively parallel sequencing technologies has allowed the characterization
of cancer genomes at an unprecedented resolution. Investigation of the mutational …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in …

The sequencing of cancer genomes may enable tailoring of therapeutics to the underlying
biological abnormalities driving a particular patient's tumor. However, sequencing-based …

Abstract Approximately 1–5% of breast cancers are attributed to inherited mutations in
BRCA1 or BRCA2 and are selectively sensitive to poly (ADP-ribose) polymerase (PARP) …

Spatial and temporal dissection of the genomic changes occurring during the evolution of
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal …

Patterns of genomic evolution between primary and metastatic breast cancer have not been
studied in large numbers, despite patients with metastatic breast cancer having dismal …