User profiles for "author:Ke Hao"

Ke Hao

- Verified email at mssm.edu - Cited by 19544

Hao-Ren Ke

- Verified email at ntnu.edu.tw - Cited by 1709

[HTML][HTML] Opportunities and challenges for transcriptome-wide association studies

M Wainberg, N Sinnott-Armstrong, N Mancuso… - Nature …, 2019 - nature.com
Transcriptome-wide association studies (TWAS) integrate genome-wide association studies
(GWAS) and gene expression datasets to identify gene–trait associations. In this …

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

AS Dimas, V Lagou, A Barker, JW Knowles, R Mägi… - Diabetes, 2014 - Am Diabetes Assoc
Patients with established type 2 diabetes display both β-cell dysfunction and insulin
resistance. To define fundamental processes leading to the diabetic state, we examined the …

Air pollution and chronic obstructive pulmonary disease

RR Duan, K Hao, T Yang - Chronic diseases and translational …, 2020 - mednexus.org
There is considerable epidemiological evidence indicating that air pollution has adverse
effects on human health and is closely related to respiratory diseases, including chronic …

Hundreds of variants clustered in genomic loci and biological pathways affect human height

H Lango Allen, K Estrada, G Lettre, SI Berndt… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …

[HTML][HTML] Mapping the genetic architecture of gene expression in human liver

EE Schadt, C Molony, E Chudin, K Hao, X Yang… - PLoS …, 2008 - journals.plos.org
Genetic variants that are associated with common human diseases do not lead directly to
disease, but instead act on intermediate, molecular phenotypes that in turn induce changes …

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

WK Sung, H Zheng, S Li, R Chen, X Liu, Y Li, NP Lee… - Nature …, 2012 - nature.com
To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted
massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular …

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

NM Warrington, RN Beaumont, M Horikoshi, FR Day… - Nature …, 2019 - nature.com
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

Z Kan, H Zheng, X Liu, S Li, TD Barber, Z Gong… - Genome …, 2013 - genome.cshlp.org
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no
effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely …

Text summarization using a trainable summarizer and latent semantic analysis

JY Yeh, HR Ke, WP Yang, IH Meng - Information processing & management, 2005 - Elsevier
This paper proposes two approaches to address text summarization: modified corpus-based
approach (MCBA) and LSA-based TRM approach (LSA+ TRM). The first is a trainable …

Particulate matter exposure and stress hormone levels: a randomized, double-blind, crossover trial of air purification

H Li, J Cai, R Chen, Z Zhao, Z Ying, L Wang, J Chen… - Circulation, 2017 - Am Heart Assoc
Background: Exposure to ambient particulate matter (PM) is associated with a number of
adverse health outcomes, but potential mechanisms are largely unknown. Metabolomics …