[HTML][HTML] Opportunities and challenges for transcriptome-wide association studies
Transcriptome-wide association studies (TWAS) integrate genome-wide association studies
(GWAS) and gene expression datasets to identify gene–trait associations. In this …
(GWAS) and gene expression datasets to identify gene–trait associations. In this …
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity
Patients with established type 2 diabetes display both β-cell dysfunction and insulin
resistance. To define fundamental processes leading to the diabetic state, we examined the …
resistance. To define fundamental processes leading to the diabetic state, we examined the …
Air pollution and chronic obstructive pulmonary disease
RR Duan, K Hao, T Yang - Chronic diseases and translational …, 2020 - mednexus.org
There is considerable epidemiological evidence indicating that air pollution has adverse
effects on human health and is closely related to respiratory diseases, including chronic …
effects on human health and is closely related to respiratory diseases, including chronic …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
H Lango Allen, K Estrada, G Lettre, SI Berndt… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …
sequence variants at many genetic loci influence the phenotype. Genome-wide association …
[HTML][HTML] Mapping the genetic architecture of gene expression in human liver
Genetic variants that are associated with common human diseases do not lead directly to
disease, but instead act on intermediate, molecular phenotypes that in turn induce changes …
disease, but instead act on intermediate, molecular phenotypes that in turn induce changes …
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted
massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular …
massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular …
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no
effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely …
effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely …
Text summarization using a trainable summarizer and latent semantic analysis
This paper proposes two approaches to address text summarization: modified corpus-based
approach (MCBA) and LSA-based TRM approach (LSA+ TRM). The first is a trainable …
approach (MCBA) and LSA-based TRM approach (LSA+ TRM). The first is a trainable …
Particulate matter exposure and stress hormone levels: a randomized, double-blind, crossover trial of air purification
Background: Exposure to ambient particulate matter (PM) is associated with a number of
adverse health outcomes, but potential mechanisms are largely unknown. Metabolomics …
adverse health outcomes, but potential mechanisms are largely unknown. Metabolomics …