Aging is associated with impairments in homeostasis. Although aging and senescence are
not equivalent, the number of senescent cells increases with aging. Cellular senescence …

Cigarette smoke, containing reactive oxygen species, is the most important risk factor for
chronic pulmonary emphysema (CPE). Heme oxygenase-1 (HO-1) plays a protective role as …

Study objective To evaluate the effect of anticoagulant therapy on the survival of patients
with idiopathic pulmonary fibrosis (IPF). Design Prospective study. Setting Five hospitals …

Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron …

Reepithelialization of remodeled air spaces with bronchial epithelial cells is a prominent
pathological finding in idiopathic pulmonary fibrosis (IPF) and is implicated in IPF …

The mechanisms underlying interferon (IFN)-induced antiviral states are not well
understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator …

Autophagy, a process that helps maintain homeostatic balance between the synthesis,
degradation, and recycling of organelles and proteins to meet metabolic demands, plays an …

Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen
species (ROS) production has been implicated in COPD pathogenesis by accelerating …

Tobacco smoke-induced accelerated cell senescence has been implicated in the
pathogenesis of chronic obstructive pulmonary disease (COPD). Cell senescence is …

Mitochondria are dynamic organelles that continuously change their shape through fission
and fusion. Disruption of mitochondrial dynamics is involved in disease pathology through …