The mutated gene responsible for the tubby obesity phenotype has been identified by
positional cloning. A single base change within a splice donor site results in the incorrect …

Since its start, the Mammalian Gene Collection (MGC) has sought to provide at least one full-
protein-coding sequence cDNA clone for every human and mouse gene with a RefSeq …

We report a collection of tri-and tetranucleotide repeat sequence polymorphic markers used
to construct genome-wide human linkage maps. Using a strategy of marker selection to …

Maturity-onset diabetes of the young 3 (MODY3) is a type of NIDDM caused by mutations in
the transcription factor hepatocyte nuclear factor-1a (HNF-1α) located on chromosome 12q …

Poh1 deubiquitinase activity is required for proteolytic processing of polyubiquitinated
substrates by the 26S proteasome, linking deubiquitination to complete substrate …

Genetic markers based upon PCR amplification of short tandem repeat-containing
sequence tagged sites (STSs) have become the standard for genetic mapping. We have …

In this report, we describe the successful application of a rapid and efficient procedure,
based on subtractive hybridization and PCR amplification, for generating microsatellite …

Background Expression of the T-cell-associated chemokine receptor CCR8 and its ligand
CCL1 have been demonstrated to be elevated in patients with asthma. CCR8 deficiency or …

The expansion of a (CAG/CTG) ntriplet repeat has been found to be associated with at least
seven genetic diseases, suggesting that this mechanism of disease may be fairly common …

Two thousand nine hundred and thirty-one tri-and tetranucleotide short tandem repeat
polymorphisms (STRPs) developed by the Cooperative Human Linkage Center were …