User profiles for "author:H McShane"
 | Helen McShaneThe Jenner Institute, University of Oxford Verified email at ndm.ox.ac.uk Cited by 19281 |
The human immune response to tuberculosis and its treatment: a view from the blood
The immune response upon infection with the pathogen Mycobacterium tuberculosis is
poorly understood, hampering the discovery of new treatments and the improvements in …
poorly understood, hampering the discovery of new treatments and the improvements in …
Tuberculosis vaccines: beyond bacille Calmette–Guérin
H McShane - … transactions of the royal society B …, 2011 - royalsocietypublishing.org
Tuberculosis (TB) disease caused by Mycobacterium tuberculosis (M. tb) remains one of the
leading infectious causes of death and disease throughout the world. The only licensed …
leading infectious causes of death and disease throughout the world. The only licensed …
[HTML][HTML] Antibodies and tuberculosis
…, J Mongkolsapaya, GR Screaton, H McShane… - Tuberculosis, 2016 - Elsevier
Tuberculosis (TB) remains a major public health problem internationally, causing 9.6 million
new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine …
new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine …
[HTML][HTML] Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial
…, GD Hussey, WA Hanekom, H Mahomed, H McShane - The Lancet, 2013 - thelancet.com
Background BCG vaccination provides incomplete protection against tuberculosis in infants.
A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was …
A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was …
[HTML][HTML] Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults
…, B Löndt, T Wilkinson, S Harden, H McShane… - Nature Medicine, 2022 - nature.com
Since its emergence in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has caused hundreds of millions of cases and continues to circulate globally. To establish …
2) has caused hundreds of millions of cases and continues to circulate globally. To establish …
COVID-19 vaccine hesitancy in the UK: the Oxford coronavirus explanations, attitudes, and narratives survey (Oceans) II
BackgroundOur aim was to estimate provisional willingness to receive a coronavirus 2019
(COVID-19) vaccine, identify predictive socio-demographic factors, and, principally …
(COVID-19) vaccine, identify predictive socio-demographic factors, and, principally …
[HTML][HTML] Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
Protective immunity against Mycobacterium tuberculosis depends on the generation of a
TH1-type cellular immune response, characterized by the secretion of interferon-γ (IFN-γ) …
TH1-type cellular immune response, characterized by the secretion of interferon-γ (IFN-γ) …
Rapid Detection of Mycobacterium tuberculosisInfection by Enumeration of Antigen-specific T Cells
There is no reliable means of detecting latent M. tuberculosis infection, and even in patients
with active tuberculosis, infection is often unconfirmed. We hypothesized that M. tuberculosis …
with active tuberculosis, infection is often unconfirmed. We hypothesized that M. tuberculosis …
Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guerin vaccine using mucosal administration and boosting …
NP Goonetilleke, H McShane, CM Hannan… - The Journal of …, 2003 - journals.aai.org
Heterologous prime-boost immunization strategies can evoke powerful T cell immune
responses and may be of value in developing an improved tuberculosis vaccine. We show …
responses and may be of value in developing an improved tuberculosis vaccine. We show …
[HTML][HTML] Effects of different types of written vaccination information on COVID-19 vaccine hesitancy in the UK (OCEANS-III): a single-blind, parallel-group, randomised …
Background The effectiveness of the COVID-19 vaccination programme depends on mass
participation: the greater the number of people vaccinated, the less risk to the population …
participation: the greater the number of people vaccinated, the less risk to the population …