Background COVID-19 has overwhelmed health services globally. Oral antiviral therapies
are licensed worldwide, but indications and efficacy rates vary. We aimed to evaluate the …

National surveys have revealed significant differences in patient outcomes following
admission to hospital with acute exacerbation of COPD which are likely to be due to …

Background: COPD and radiographic bronchiectasis frequently coexist but the effect of this
on the clinical course of COPD is not fully understood. We determined the impact of …

Background Severe exacerbations of COPD are commonly associated with hyperglycaemia,
which predicts adverse outcomes. Metformin is a well-established anti-hyperglycaemic …

Altered airway smooth muscle (ASM) function and enrichment of the extracellular matrix
(ECM) with interstitial collagen and fibronectin are major pathological features of airway …

Airway smooth muscle (ASM) is a potential source of multiple proinflammatory cytokines
during airway inflammation. In the present study, we examined a requirement for mitogen …

Background Non-invasive ventilation (NIV) can increase exercise tolerance, reduce exercise
induced desaturation and improve the outcome of pulmonary rehabilitation in patients with …

Despite an increased understanding of the aetiology and pathogenesis of bronchial asthma,
attempts to classify its severity have proved difficult. Objective changes in cardiopulmonary …

Rehearse for life in clinical practice with this easy-to-use and unique series, which combines
cases drawn from real-life experiences with a refreshing approach to presentations as you …

Rationale. studies have used HRCT to describe COPD phenotypes, which now need further
clinical and prognostic characterization. We determined the relative impact of increasing …