Ionotropic glutamate receptors (iGluRs) mediate the vast majority of fast excitatory synaptic
transmissions within the mammalian central nervous system (CNS). As for other ion channel …

A number of pathogens induce immature dendritic cells (iDC) to migrate to lymphoid organs
where, as mature DC (mDC), they serve as efficient APC. We hypothesized that pathogen …

Background It has been thought that Clostridium difficile infection is transmitted
predominantly within health care settings. However, endemic spread has hampered …

The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug
resistance in clinical samples, and improvements in global surveillance. Here we show how …

Ionotropic glutamate receptors mediate the vast majority of fast excitatory synaptic
transmission in the CNS. Elucidating the structure of these proteins is central to …

Intrinsic antioxidant defenses are important for neuronal longevity. We found that in rat
neurons, synaptic activity, acting via NMDA receptor (NMDAR) signaling, boosted …

Homeostatic processes that regulate electrical activity in neurones are now an established
aspect of physiology and rest on a large body of experimental evidence that points to roles …

NR2A and NR2B are the predominant NR2 NMDA receptor subunits expressed in cortex
and hippocampus. The relative expression level of NR2A and NR2B is regulated …

Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in
amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration …

Summary Background The control of Clostridium difficile infections is an international clinical
challenge. The incidence of C difficile in England declined by roughly 80% after 2006 …