Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

The long-term solution to the asthma epidemic is thought to be prevention, and not treatment
of established disease. Atopic asthma arises from gene–environment interactions, which …

Vitamin D, in addition to its classical functions in bone homeostasis, has a modulatory and
regulatory role in multiple processes, including host defense, inflammation, immunity, and …

Background A rich microbial environment in infancy protects against asthma, and infections
precipitate asthma exacerbations. We compared the airway microbiota at three levels in …

Community-based surveys show that parentalreported cough as an isolated symptom has a
high prevalence. 2 3 Reported cough without colds has a prevalence of 28% in boys and …

This document provides clinical recommendations for the management of severe asthma.
Comprehensive evidence syntheses, including meta-analyses, were performed to …

Background. Respiratory syncytial virus (RSV) disease severity was thought to be a result of
host immunopathology but alternatively may be driven by high-level viral replication. The …

Background Maximal expiratory airflow peaks early in the third decade of life, then gradually
declines with age. The pattern of airflow through adulthood for individuals born very preterm …

Introduction Asthma attacks are responsible for considerable morbidity and may be fatal. We
aimed to identify and weight risk factors for asthma attacks in children (5–12 years) in order …

Background Children's interstitial lung diseases (chILD) cover many rare entities, frequently
not diagnosed or studied in detail. There is a great need for specialised advice and for …