[PDF][PDF] PRIMPOL-mediated adaptive response suppresses replication fork reversal in BRCA-deficient cells

A Quinet, S Tirman, J Jackson, S Šviković, D Lemaçon… - Molecular cell, 2020 - cell.com
Acute treatment with replication-stalling chemotherapeutics causes reversal of replication
forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss …

Microenvironment and autophagy cross-talk: Implications in cancer therapy

LR Gomes, AT Vessoni, CFM Menck - Pharmacological research, 2016 - Elsevier
There are many ongoing clinical trials to validate tumour microenvironment or autophagic
pathway components as targets for anticancer therapies. Different components of the tumour …

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome

A Quinet, AT Vessoni, CRR Rocha, V Gottifredi, D Biard… - DNA repair, 2014 - Elsevier
Ultraviolet (UV)-induced DNA damage are removed by nucleotide excision repair (NER) or
can be tolerated by specialized translesion synthesis (TLS) polymerases, such as Polη. TLS …

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

LK Lerner, G Francisco, DT Soltys… - Nucleic acids …, 2017 - academic.oup.com
Genome lesions trigger biological responses that help cells manage damaged DNA,
improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses …

Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony

AT Vessoni, RH Herai, JV Karpiak… - Human molecular …, 2016 - academic.oup.com
Cockayne syndrome (CS) is a rare genetic disorder in which 80% of cases are caused by
mutations in the Excision Repair Cross-Complementation group 6 gene (ERCC6). The …

[HTML][HTML] Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus

E Cararo-Lopes, MH Dias, MS da Silva… - Cell Death & …, 2021 - nature.com
Malignant transformation involves an orchestrated rearrangement of cell cycle regulation
mechanisms that must balance autonomic mitogenic impulses and deleterious oncogenic …

Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe

AT Vessoni, T Zhang, A Quinet, HC Jeong… - Journal of Cell …, 2021 - rupress.org
It is well established that short telomeres activate an ATM-driven DNA damage response
that leads to senescence in terminally differentiated cells. However, technical limitations …

Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation

JR Brestoff, AT Vessoni, KA Brenner, GL Uy… - Thorax, 2018 - thorax.bmj.com
Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase
reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become …

Correction: Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus

E Cararo-Lopes, MH Dias, MS da Silva… - Cell Death & …, 2021 - nature.com
Correction: Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation
in keratinocytes primed by human papillomavirus | Cell Death & Disease Skip to main content …

Abstract A34: Microenvironment controls breast cancer cells sensitivity to doxorubicin by autophagy inhibition

LR Gomes, AT Vessoni, CFM Menck - Cancer Research, 2013 - AACR
Drug chemotherapy resistance is the leading cause of death for cancer patients. Most of the
studies involving chemotherapy resistance are based on experiments making use of cancer …