Human airway smooth muscle (ASM) has several properties and functions that contribute to
asthma pathogenesis, and increasing attention is being paid to its synthetic capabilities …

Studies now show that the airway smooth muscle cell, in addition to its contractile function,
can participate in and coordinate the inflammatory response. In response to inflammatory …

Airway smooth muscle (ASM) plays an important role in asthma pathophysiology through its
contractile and proliferative functions. The cyclic nucleotides adenosine 3′, 5′-cyclic …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …

Background Inflammation and oxidative stress play critical roles in patients with chronic
obstructive pulmonary disease (COPD). Mitochondrial oxidative stress might be involved in …

We have investigated the relation between lung function and dietary intake of the antioxidant
vitamins C and E in the general population in a cross-sectional survey of a random sample …

Thirty six patients with chronic airflow obstruction were studied to examine (1) the
reproducibility and order effect of repeated walking tests when performed over consecutive …

In the FANTOM5 project, transcription initiation events across the human and mouse
genomes were mapped at a single base-pair resolution and their frequencies were …

Activation of latent transforming growth factor β (TGF-β) by αvβ6 integrin is critical in the
pathogenesis of lung injury and fibrosis. We have previously demonstrated that the …

To investigate whether cessation of regular β-agonist treatment results in an increase in
bronchial responsiveness, two double-blind, randomised crossover studies were done …