Abstract
The effect on total pulmonary resistance (R1) was examined for inhaled PACAP 1-38, PACAP 1-27 and VIP in anesthetized, ventilated guinea pigs. Two minutes after inhalation, PACAP 1-38 (36 +/- 6%), PACAP 1-27 (42 +/- 9%) and VIP (48 +/- 19%) inhibited the increase in R1 (% inhibition of histamine-induced R1 prior to inhalation) caused by histamine i.v., whereas the vehicle (-1 +/- 10%) did not. This inhibitory effect lasted five times longer for PACAP 1-38 (> 50 min) than for PACAP 1-27 and VIP (< 10 min). The inhaled peptides caused no sustained effects on heart rate or blood pressure. Infusion of PACAP 1-38 i.v. dose-dependently inhibited the increase in R1 caused by inhaled histamine and by carbachol i.v..
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Inhalation
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Airway Resistance / drug effects*
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Animals
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Blood Pressure / drug effects
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Bronchodilator Agents / administration & dosage
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Bronchodilator Agents / pharmacology*
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Carbachol / pharmacology
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Guinea Pigs
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Heart Rate / drug effects
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Histamine / pharmacology
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Lung / drug effects*
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Male
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Neuropeptides / administration & dosage
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Neuropeptides / pharmacology*
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Peptide Fragments / administration & dosage
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Peptide Fragments / pharmacology*
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Pituitary Adenylate Cyclase-Activating Polypeptide
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Vasoactive Intestinal Peptide / administration & dosage
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Vasoactive Intestinal Peptide / pharmacology*
Substances
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Bronchodilator Agents
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Neuropeptides
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Peptide Fragments
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Pituitary Adenylate Cyclase-Activating Polypeptide
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pituitary adenylate cyclase-activating-peptide (1-38), pig
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Vasoactive Intestinal Peptide
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Histamine
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Carbachol