Abstract
Three parallel studies on screening for lung cancer, supported by the National Cancer Institute, were carried out by the Mayo Clinic, Johns Hopkins Medical Institutions, and Memorial Sloan-Kettering Center from 1971 to 1982. No significant mortality improvement was established that could be attributed to cytologic screening examinations. Many stage I lung cancers were detected by radiographic screening, with excellent changes for long-term survival. Patients with stage I cancers who were operated on had significantly better survival rates than those who failed to undergo surgery. Statistical modeling, however, indicates that long-term annual screening of a high-risk population would decrease lung cancer mortality by no more than 18%.
Publication types
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Clinical Trial
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Multicenter Study
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Randomized Controlled Trial
MeSH terms
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Adenocarcinoma / diagnosis
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Adenocarcinoma / mortality
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Adenocarcinoma / prevention & control*
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Adenocarcinoma / surgery
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Aged
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Aged, 80 and over
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Carcinoma, Non-Small-Cell Lung / diagnosis
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Carcinoma, Non-Small-Cell Lung / mortality
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Carcinoma, Non-Small-Cell Lung / prevention & control*
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Carcinoma, Non-Small-Cell Lung / surgery
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Carcinoma, Small Cell / diagnosis
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Carcinoma, Small Cell / mortality
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Carcinoma, Small Cell / prevention & control*
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Carcinoma, Small Cell / surgery
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Carcinoma, Squamous Cell / diagnosis
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / prevention & control*
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Carcinoma, Squamous Cell / surgery
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Clinical Protocols
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Humans
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Incidence
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Lung Neoplasms / diagnosis
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Lung Neoplasms / mortality
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Lung Neoplasms / prevention & control*
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Lung Neoplasms / surgery
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Male
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Mass Screening / methods*
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Middle Aged
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Models, Theoretical
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Neoplasm Staging
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Prevalence
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Prognosis
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Smoking
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Survival Rate
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Time Factors
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United States