The modification and assembly of proteins in the endoplasmic reticulum

Curr Opin Cell Biol. 1993 Aug;5(4):589-95. doi: 10.1016/0955-0674(93)90127-c.

Abstract

Proteins fold and assemble in the endoplasmic reticulum in an environment that is very different from the cytosol. The presence of relatively high concentrations of calcium, an oxidizing state, ATP and lumenal proteins are all important in mediating these events.

Publication types

  • Review

MeSH terms

  • Animals
  • Chaperonins
  • Chemical Phenomena
  • Chemistry, Physical
  • Endoplasmic Reticulum / chemistry*
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Peptides / metabolism
  • Protein Folding
  • Proteins / chemistry

Substances

  • Membrane Proteins
  • Peptides
  • Proteins
  • Chaperonins