Increased coexpression of CFTR and S100 calcium binding proteins MRP8 and MRP14 mRNAs in cystic fibrosis human tracheal gland cells

Biochem Biophys Res Commun. 1994 Jun 30;201(3):1518-25. doi: 10.1006/bbrc.1994.1876.

Abstract

We have demonstrated for the first time, by Northern analysis, the presence of the S-100 calcium binding proteins MRP8 (also called "cystic fibrosis protein") and MRP14 mRNAs in cultured human tracheal gland cells, obtained from normal and cystic fibrosis (CF) patients. A significant increase of these mRNAs in cells of CF origin (as well as that of CFTR mRNA) is shown. These results allow us to assume a potential pretranslational regulation of MRP8 and MRP14 gene expression related to the presence of a mutated CFTR gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Differentiation / genetics*
  • Calcium-Binding Proteins / genetics*
  • Calgranulin A
  • Calgranulin B
  • Colon / metabolism
  • Cystic Fibrosis / genetics*
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Gene Expression
  • Humans
  • Membrane Proteins / metabolism*
  • RNA, Messenger / genetics
  • Trachea / physiology*

Substances

  • Antigens, Differentiation
  • CFTR protein, human
  • Calcium-Binding Proteins
  • Calgranulin A
  • Calgranulin B
  • Membrane Proteins
  • RNA, Messenger
  • Cystic Fibrosis Transmembrane Conductance Regulator