Abstract
We have demonstrated for the first time, by Northern analysis, the presence of the S-100 calcium binding proteins MRP8 (also called "cystic fibrosis protein") and MRP14 mRNAs in cultured human tracheal gland cells, obtained from normal and cystic fibrosis (CF) patients. A significant increase of these mRNAs in cells of CF origin (as well as that of CFTR mRNA) is shown. These results allow us to assume a potential pretranslational regulation of MRP8 and MRP14 gene expression related to the presence of a mutated CFTR gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Differentiation / genetics*
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Calcium-Binding Proteins / genetics*
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Calgranulin A
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Calgranulin B
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Colon / metabolism
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Cystic Fibrosis / genetics*
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Cystic Fibrosis Transmembrane Conductance Regulator
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Gene Expression
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Humans
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Membrane Proteins / metabolism*
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RNA, Messenger / genetics
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Trachea / physiology*
Substances
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Antigens, Differentiation
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CFTR protein, human
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Calcium-Binding Proteins
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Calgranulin A
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Calgranulin B
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Membrane Proteins
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RNA, Messenger
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Cystic Fibrosis Transmembrane Conductance Regulator