Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing

Nature. 1984;312(5996):729-34. doi: 10.1038/312729a0.

Abstract

A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cattle
  • Cloning, Molecular
  • Gene Expression Regulation
  • Genes
  • Nerve Tissue Proteins / genetics*
  • Nervous System Physiological Phenomena
  • Peptides / genetics*
  • Protein Precursors / genetics*
  • RNA Splicing*
  • RNA, Messenger / genetics
  • Substance P / genetics*
  • Tachykinins
  • Tissue Distribution

Substances

  • Nerve Tissue Proteins
  • Peptides
  • Protein Precursors
  • RNA, Messenger
  • Tachykinins
  • preprotachykinin
  • Substance P

Associated data

  • GENBANK/M14786
  • GENBANK/X00075
  • GENBANK/X00076
  • GENBANK/X01395
  • GENBANK/X01396
  • GENBANK/X01397
  • GENBANK/X01398
  • GENBANK/X01399
  • GENBANK/X01400
  • GENBANK/X01401
  • GENBANK/X02351