Abstract
A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cattle
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Cloning, Molecular
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Gene Expression Regulation
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Genes
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Nerve Tissue Proteins / genetics*
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Nervous System Physiological Phenomena
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Peptides / genetics*
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Protein Precursors / genetics*
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RNA Splicing*
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RNA, Messenger / genetics
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Substance P / genetics*
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Tachykinins
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Tissue Distribution
Substances
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Nerve Tissue Proteins
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Peptides
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Protein Precursors
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RNA, Messenger
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Tachykinins
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preprotachykinin
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Substance P
Associated data
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GENBANK/M14786
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GENBANK/X00075
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GENBANK/X00076
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GENBANK/X01395
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GENBANK/X01396
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GENBANK/X01397
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GENBANK/X01398
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GENBANK/X01399
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GENBANK/X01400
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GENBANK/X01401
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GENBANK/X02351