Abstract
Twelve patients with Wegener's granulomatosis were treated with antimicrobial agents, chiefly trimethoprim-sulfamethoxazole. The clinical course improved in 11 of the 12 patients who received this treatment. The success of antimicrobial treatment suggests the possibility of a microbial infection as the inciting cause of Wegener's granulomatosis in some patients. Alternatively, these agents--in particular, trimethoprim-sulfamethoxazole--may possess immunosuppressant activity.
MeSH terms
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Adult
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Aged
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Cyclophosphamide / therapeutic use
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Drug Combinations / therapeutic use
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Drug Therapy, Combination
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Female
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Granulomatosis with Polyangiitis / drug therapy*
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Granulomatosis with Polyangiitis / pathology
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Humans
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Lung / pathology
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Male
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Middle Aged
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Nose / pathology
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Prednisone / therapeutic use
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Sulfamethoxazole / therapeutic use*
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Trimethoprim / therapeutic use*
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Trimethoprim, Sulfamethoxazole Drug Combination
Substances
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Drug Combinations
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Trimethoprim, Sulfamethoxazole Drug Combination
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Cyclophosphamide
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Trimethoprim
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Sulfamethoxazole
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Prednisone