A controlled trial of nebulized aminoglycoside and oral flucloxacillin versus placebo in the outpatient management of children with cystic fibrosis

F Carswell; C Ward; D A Cook; D C Speller

doi:10.1016/0007-0971(87)90184-7

A controlled trial of nebulized aminoglycoside and oral flucloxacillin versus placebo in the outpatient management of children with cystic fibrosis

Br J Dis Chest. 1987 Oct;81(4):356-60. doi: 10.1016/0007-0971(87)90184-7.

Authors

F Carswell¹, C Ward, D A Cook, D C Speller

Affiliation

¹ Department of Child Health, University of Bristol.

PMID: 3329531
DOI: 10.1016/0007-0971(87)90184-7

Abstract

Six children with cystic fibrosis who had persistently had Pseudomonas aeruginosa isolated from their respiratory tract, completed a double-blind cross-over comparison of oral flucloxacillin and nebulized aminoglycoside versus double placebo. The patients had higher FEV1 results at the end of the month of active treatment than after the month of placebo.

Publication types

Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Inhalation
Administration, Oral
Adolescent
Child
Clinical Trials as Topic
Cloxacillin / analogs & derivatives*
Cystic Fibrosis / drug therapy*
Cystic Fibrosis / microbiology
Double-Blind Method
Drug Therapy, Combination
Female
Floxacillin / administration & dosage
Floxacillin / therapeutic use*
Humans
Male
Pseudomonas Infections / drug therapy
Tobramycin / administration & dosage
Tobramycin / therapeutic use*

Substances

Floxacillin
Cloxacillin
Tobramycin