Abstract
Three patients with severe, treatment-resistant cutaneous sarcoidosis were treated with low-dose oral methotrexate on a weekly basis. Facial granulomas and ulcerations responded best. A response was apparent after several weeks of treatment, but 6 to 9 months were required to reach maximal effect.
MeSH terms
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Administration, Oral
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Adult
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Drug Administration Schedule
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Female
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Granuloma / drug therapy
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Humans
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Male
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Methotrexate / administration & dosage*
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Methotrexate / therapeutic use
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Middle Aged
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Sarcoidosis / drug therapy*
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Sarcoidosis / pathology
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Skin Diseases / drug therapy*
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Skin Diseases / pathology
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Ulcer / drug therapy