Hypersensitivity pneumonitis versus invasive pulmonary aspergillosis: two cases with unusual pathologic findings and review of the literature

D P Meeker; G N Gephardt; E M Cordasco Jr; H P Wiedemann

doi:10.1164/ajrccm/143.2.431

Hypersensitivity pneumonitis versus invasive pulmonary aspergillosis: two cases with unusual pathologic findings and review of the literature

Am Rev Respir Dis. 1991 Feb;143(2):431-6. doi: 10.1164/ajrccm/143.2.431.

Authors

D P Meeker¹, G N Gephardt, E M Cordasco Jr, H P Wiedemann

Affiliation

¹ Department of Pulmonary Disease, Cleveland Clinic Foundation, OH 44195-5038.

PMID: 1990964
DOI: 10.1164/ajrccm/143.2.431

Abstract

Two brothers simultaneously exposed to moldy hay, who developed differing forms of Aspergillus-related lung disease, are presented. Patient 1 developed a true case of hypersensitivity lung disease, whereas his brother developed invasive aspergillosis with bronchoalveolar lavage eosinophilia and unusual pathologic features including tissue eosinophilia. The possible overlap between hypersensitivity pneumonitis and invasive aspergillosis in the immunocompetent host is discussed.

Publication types

Case Reports

MeSH terms

Adult
Alveolitis, Extrinsic Allergic / diagnostic imaging
Alveolitis, Extrinsic Allergic / etiology*
Antifungal Agents / therapeutic use
Aspergillosis / complications*
Aspergillosis / diagnostic imaging
Aspergillosis / drug therapy
Biopsy
Bronchoalveolar Lavage Fluid / microbiology
Bronchoalveolar Lavage Fluid / pathology
Eosinophilia / complications
Granuloma / complications
Granuloma / pathology
Humans
Lung / pathology
Lung Diseases / complications*
Lung Diseases / diagnostic imaging
Male
Radiography, Thoracic

Substances

Antifungal Agents