Abstract
The frequency of typical and atypical Beijing strains of Mycobacterium tuberculosis was determined in the Netherlands; Vietnam; and Hong Kong Special Administrative Region, People's Republic of China. The strains' associations with drug resistance, M. bovis BCG vaccination, and patient characteristics were assessed. BCG vaccination may have positively selected the prevalent typical Beijing strains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antibodies, Bacterial / immunology*
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Antigenic Variation
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Antitubercular Agents / pharmacology
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BCG Vaccine / administration & dosage*
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BCG Vaccine / immunology
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China
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DNA Transposable Elements
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Drug Resistance, Bacterial*
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Female
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Genotype
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Hong Kong
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Humans
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Isoniazid / pharmacology
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mycobacterium tuberculosis* / classification
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Mycobacterium tuberculosis* / drug effects
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Mycobacterium tuberculosis* / genetics
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Mycobacterium tuberculosis* / immunology
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Mycobacterium tuberculosis* / isolation & purification
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Netherlands
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Polymerase Chain Reaction
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Polymorphism, Restriction Fragment Length
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Risk Factors
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Tuberculosis / immunology*
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Tuberculosis / microbiology
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Tuberculosis / prevention & control
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Vaccination
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Vietnam
Substances
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Antibodies, Bacterial
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Antitubercular Agents
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BCG Vaccine
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DNA Transposable Elements
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Isoniazid