Serial testing for tuberculosis: can we make sense of T cell assay conversions and reversions?

PLoS Med. 2007 Jun;4(6):e208. doi: 10.1371/journal.pmed.0040208.

Abstract

The authors discuss a new study, which they say is a valuable addition to the existing literature on the performance of interferon gamma release assays in serial testing for TB infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antigens, Bacterial / immunology
  • BCG Vaccine
  • Bacterial Proteins / immunology
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay*
  • Female
  • Follow-Up Studies
  • Gambia / epidemiology
  • Humans
  • Interferon-gamma / analysis*
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / isolation & purification*
  • Predictive Value of Tests
  • Reproducibility of Results
  • Sensitivity and Specificity
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism*
  • Treatment Outcome
  • Tuberculin Test
  • Tuberculosis / diagnosis*
  • Tuberculosis / epidemiology
  • Tuberculosis / immunology
  • Tuberculosis / microbiology

Substances

  • Antigens, Bacterial
  • BCG Vaccine
  • Bacterial Proteins
  • CFP-10 protein, Mycobacterium tuberculosis
  • ESAT-6 protein, Mycobacterium tuberculosis
  • Interferon-gamma