Abstract
Interstitial pulmonary fibrosis induced by bleomycin (BL) involves the production of reactive oxygen species and the impairment of repair of damaged epithelial cells. We have shown previously that taurine or niacin treatment partially attenuates BL-induced lung fibrosis in hamsters and that the two agents probably act through different mechanisms. In the present investigation, we have demonstrated that taurine and niacin in combination provide nearly complete protection against BL-induced pulmonary fibrosis. Based on the findings of this investigation, it is suggested that combined treatment with taurine and niacin offers the potential for a novel pharmacological approach in the prevention of lung fibrosis in humans.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Oral
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Animals
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Bleomycin / administration & dosage
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Bleomycin / toxicity*
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Calcium / metabolism
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Cricetinae
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Drug Therapy, Combination
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Hydroxyproline / metabolism
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Injections, Intraperitoneal
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Lung / drug effects*
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Lung / metabolism
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Male
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Malondialdehyde / metabolism
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Mesocricetus
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NAD / metabolism
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Niacin / administration & dosage
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Niacin / blood
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Niacin / therapeutic use*
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Poly(ADP-ribose) Polymerases / metabolism
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Procollagen-Proline Dioxygenase / metabolism
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Pulmonary Fibrosis / chemically induced*
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Pulmonary Fibrosis / prevention & control
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Superoxide Dismutase / metabolism
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Taurine / administration & dosage
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Taurine / blood
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Taurine / therapeutic use*
Substances
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NAD
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Bleomycin
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Taurine
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Niacin
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Malondialdehyde
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Procollagen-Proline Dioxygenase
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Superoxide Dismutase
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Poly(ADP-ribose) Polymerases
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Hydroxyproline
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Calcium