On August 25, 2005, Hurricane Katrina made landfall between Hallandale Beach and Aventura, Florida, as a Category 1 hurricane, with sustained winds of 80 mph. Storm effects, primarily rain, flooding, and high winds, were substantial; certain areas reported nearly 12 inches of rainfall. After crossing southern Florida and entering the Gulf of Mexico, the hurricane strengthened and made landfall in southeastern Louisiana on August 29 as a Category 3 hurricane, with sustained winds of 125 mph. Katrina was one of the strongest hurricanes to strike the United States during the past 100 years and was likely the nation's costliest natural disaster to date. This report summarizes findings and recommendations from a review of mortality records of Florida's Medical Examiners Commission (FMEC) and the Alabama Department of Forensic Science (ADFS). CDC was invited by the Florida Department of Health (FDOH) and the Alabama Department of Public Health (ADPH) to assess the mortality related to Hurricane Katrina. The mortality review was intended to provide county-based information that would be used to 1) define the impact of the hurricane, 2) describe the etiology of deaths, and 3) identify strategies to prevent or reduce future hurricane-related mortality. Combined, both agencies identified five, 23, and 10 deaths, respectively, that were directly, indirectly, or possibly related to Hurricane Katrina. Information from the characterization of these deaths will be used to reduce hurricane-related mortality through early community awareness of hurricane-related risk, prevention measures, and effective communication of a coordinated hurricane response plan.