Abstract
This study was designed to determine if aerosolized hyaluronan (HA) could prevent airspace enlargement and elastic fiber injury in a mouse model of cigarette smoke-induced pulmonary emphysema. Compared to untreated/smoked controls, HA-treated animals showed statistically significant reductions in mean linear intercept (54 versus 65 microm; P < .001) and elastic fiber breakdown products (desmosine and isodesmosine) in bronchoalveolar lavage fluid (0.3 versus 7.0 ng/mL; P < .05). As in previous studies, the aerosolized HA showed preferential binding to elastic fibers, suggesting that it may protect them from injury. These findings support further investigation of the potential use of HA as a treatment for pulmonary emphysema.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adjuvants, Immunologic / therapeutic use*
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Administration, Inhalation
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Aerosols
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Animals
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Bronchoalveolar Lavage Fluid / chemistry
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Bronchoalveolar Lavage Fluid / cytology
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Cell Count
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Desmosine / metabolism
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Disease Models, Animal
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Elastic Tissue / drug effects
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Elastic Tissue / metabolism
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Elastic Tissue / pathology
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Female
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Hyaluronic Acid / therapeutic use*
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Isodesmosine / metabolism
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Lung / drug effects
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Lung / metabolism
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Lung / pathology
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Macrophages, Alveolar / drug effects
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Macrophages, Alveolar / pathology
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Mice
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Mice, Inbred DBA
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Pulmonary Alveoli / drug effects*
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Pulmonary Alveoli / metabolism
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Pulmonary Alveoli / pathology
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Pulmonary Emphysema / chemically induced*
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Pulmonary Emphysema / drug therapy*
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Pulmonary Emphysema / pathology
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Smoking / adverse effects*
Substances
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Adjuvants, Immunologic
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Aerosols
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Desmosine
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Hyaluronic Acid
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Isodesmosine