Animal models of cystic fibrosis

Bob J Scholte; Donald J Davidson; Martina Wilke; Hugo R De Jonge

doi:10.1016/j.jcf.2004.05.039

Animal models of cystic fibrosis

J Cyst Fibros. 2004 Aug:3 Suppl 2:183-90. doi: 10.1016/j.jcf.2004.05.039.

Authors

Bob J Scholte¹, Donald J Davidson, Martina Wilke, Hugo R De Jonge

Affiliation

¹ Department of Cell Biology, Erasmus Medical Centre, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. b.scholte@erasmusmc.nl

PMID: 15463956
DOI: 10.1016/j.jcf.2004.05.039

Abstract

Animal models of cystic fibrosis, in particular several different mutant mouse strains obtained by homologous recombination, have contributed considerably to our understanding of CF pathology. In this review, we describe and compare the main phenotypic features of these models. Recent and possible future developments in this field are discussed.

Publication types

Review

MeSH terms

Animals
Cystic Fibrosis / genetics*
Cystic Fibrosis / physiopathology*
Ferrets
Mice
Models, Animal
Mutation / genetics
Mutation / physiology
Phenotype
Sheep
Swine